Overview:

The Non-Regulated Bioanalysis group in the Quantitative, Translational & ADME Sciences Department at AbbVie has an opening for a Senior Scientist I position in North Chicago, IL to perform small molecule bioanalysis supporting drug discovery and development. The successful candidate will be responsible for independently conducting quantitative LC-MS/MS bioanalysis in support of in-vivo PK/PD/TK studies, along with providing insight and answering technologic or key scientific questions to collaborators and junior scientists.
Duties will be focused on laboratory work, scientifically advising the Non-Regulated Bioanalysis Team, managing and/or mentoring junior analysts, and collaborating with leaders from the Operations, In-Vitro Bioanalysis, and Custom/Method Development groups.
It would be advantageous for the candidate to have practical experience performing in-vivo LC-MS/MS quantitative studies, analytical method development, investigating and implementing novel analyte extraction and LC-MS techniques to improve to improve data quality and workflow efficiency, and possess strong interpersonal, written, and oral communication skills.

Key Responsibilities:

• Perform quantitative LC-MS/MS analysis of small molecules to provide bioanalytical support for PK/PD, efficacy, and exploratory toxicology studies meeting customer satisfaction and project timelines.
• Act as scientific advisor/mentor and quality control specialist for the Non-Regulated Bioanalysis Team.
• Serve as scientific interface and close partner to other teams for bioanalytical support and development/operationalization of novel assays.
• Keep informed of literature and advances in analytical methodologies and equipment, evaluating, proposing, and implementing new technologies to meet the demand, throughput, turnaround time, and challenging assay requirements while maintaining effective resource utilization and confidence in data quality.
• Routinely operate LC-MS/MS instrumentation, including maintenance, troubleshooting, identification and resolution of instrument and assay problem.
• Write or contribute to study reports for regulatory submissions

Education/Experience:

• PhD (0+ years), M.S. (8+ years) or BS (10+ years) in analytical chemistry or related field with relevant academic or industry experience.
• Proven experience in small molecule quantitative bioanalysis using LC-MS/MS. Hands-on experience with one or more current LC-MS/MS platforms (e.g., Agilent HPLCs, Leap/CTC PAL autosamplers, RapidFire, ADDA, Sciex triple quads), software and databases (e.g., Discovery Quant, Analyst, Electronic Laboratory Notebooks, LIMS); familiarity with automated sample preparation platforms.
• Working experience in regulated bioanalysis and/or CRO/University Core facility settings will be a plus.
• Knowledge of in-vitro ADME science/in-vivo assays with an understanding of both experimental design and analytical practices will be a plus.
• Maintain creative and flexible thinking, willing to challenge the status quo, develop and/or adopt relevant emerging technologies including high-throughput and automated solutions.
• Proven ability to work in a team environment and ability to interact with interdisciplinary project teams.
• Highly motivated and self-driven with the ability to quickly adapt to different projects.
• Excellent written and oral communication skills.

AbbVie is an equal opportunity employer including disability/vets. It is AbbVie’s policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a disabled veteran, recently separated veteran, Armed Forces service medal veteran or active duty wartime or campaign badge veteran or a person’s relationship or association with a protected veteran, including spouses and other family members, or any other protected group status. We will take affirmative action to employ and advance in employment qualified minorities, women, individuals with a disability, disabled veterans, recently separated veterans, Armed Forces service medal veterans or active-duty wartime or campaign badge veterans. The Affirmative Action Plan is available for viewing in the Human Resources office during regular business hours.